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In this review, we will focus on the major challenges of msc therapies and the underlying factors leading to the failure of clinical trials The lack of comprehensive understanding regarding msc stemness greatly hampers the translation of research findings into successful clinical application due to unclear mechanism of action.

Recent advances and prospects concerning the translation of msc techniques into clinical practices will also be discussed. In this review, we shed light on challenges and recent advances surrounding stem cell therapies for wound healing and discuss limitations for their clinical adoption Clinical trials of mesenchymal stromal cell therapies reveal a challenging heterogeneous landscape, including diverse therapeutic targets, patient categories, cell sources, and potential mechanisms of action.

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In this review, we intend to address some problems and critically discuss the complex nature of mscs in the context of their effective and safe applications in regenerative medicine in different diseases including graft versus host disease (gvhd) and cardiac, neurological, and orthopedic disorders

Advances in stem cell technology offer new possibilities for patients with untreated diseases and disorders

In summary, application of mscs in the setting of trauma and coagulopathy presents unique opportunities and challenges that have received comparatively little attention to date.

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