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Circulating endothelial cells (cecs) and bmecs (cbmecs) with a mature phenotype, derived from systemic and bbb vessel turnover, respectively, are increased in patients with systemic inflammation and bbb disorders. In addition to providing a system for studying the unique cell biology of this cell type, brain microvessel endothelial cells are readily available for studying general microvessel endothelial cell properties.

Since the bbb is mainly constituted by the specific endothelial cells, called bmecs, it seems plausible that circulating bmecs (cbmecs) could be biomarkers for bbb dysfunctions. Proteomics combined with mechanistic studies indicate that cbmecs are important indicators of bbb/cns disorders in severe hfmd. This article is based on current research, according to the sequence of e