Here, we discuss the strengths and pitfalls of various techniques commonly used to analyze synapses, including miniature excitatory/inhibitory (e/i) postsynaptic currents, evoked release, and optogenetic stimulation. This study shows that pharmacological activation of cbp/p300 promotes histone acetylation and regenerative gene expression, counteracting retraction and promoting growth of sensory and motor axons in a mouse model of chronic spinal cord injury with severe disability. The final version may differ slightly in style or formatting and will contain links to any extended data.
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