Authors note that tumors likely employ a variety of strategies to evade immune detection This discovery could have major implications for cancer therapy. But the discovery could lead to a new approach for targeted cancer therapies.
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The idea to reactivate silenced sting signaling in tumors builds on prior research showing that cancer cells often suppress cgas and sting through epigenetic mechanisms.
By blocking the interactions between checkpoint receptors and their ligands, the lymphocytes can avoid inactivation and effectively target the cancer cells.
Investigators from mass general brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. Cancer cells can exploit these immune checkpoints to evade immune surveillance
